What happens in Ponyville is up to you. She could settle as a hermit, go on a rampage or simply drift apart. Or, against all odds, be best buds with her former friends again.
I've been entertaining ideas for a sequel of MS:S.
Things I know for sure: Setting: This will be set in the period when the Equis Accord is getting their feet wet in the galaxy - like the humans just after the First Contact War. It will feature 1 (canon) character from the games. It will feature totally new OCs. And an all OC cast. Or mostly OC cast.