I have just read approximately all of the "Humans are Space Orcs"/"Earth is Space Australia" stuff. All of it. There was a lot of it.
Naturally, my brain was like, "how can I connect this to MLP?"
What I came up with:
Ponyville regularly gets attacked by monsters and villains. It's situated on the edge of a forest so dangerous nopony except the most powerful or foolhardy individuals goes in.