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Aspadol is a brand name for the prescription medication tapentadol, which is used to manage moderate to severe pain. It is particularly effective in cases where other pain relief methods, such as non-opioid pain relievers, have not been successful. Aspadol is available in various strengths, including commonly prescribed dosages like 50mg, 75mg, and 100mg.

Forms and Usage

Aspadol comes in both immediate-release and extended-release formulations:

• Immediate-release (IR) tablets are typically used for the relief of acute pain that requires immediate attention, such as pain following surgery or an injury.
• Extended-release (ER) tablets are used for long-term management of chronic pain, providing a steady release of tapentadol over an extended period to maintain consistent pain control.

Mechanism of Action

Aspadol works through a dual mechanism:

1. Opioid receptor activity: It binds to certain receptors in the brain known as mu-opioid receptors, which helps to reduce the sensation of pain.
2. Norepinephrine reuptake inhibition: It inhibits the reuptake of norepinephrine, a neurotransmitter associated with mood and pain perception, thereby increasing its levels and enhancing analgesic effects.

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