Getting lost in time and space can lead to interesting incidents. Especially if your companions are a farmer, a weatherpony and a seamstress who collectively can't seem to stay out of trouble.
Applejack, Rarity and Rainbow Dash, three of Equestria's greatest heroes, and a mysterious old Diamond Dog calling himself the Doctor, have found themselves traveling through space and time with nary a clue as to their next destination. They seek their home, all while trying to deal with the local issues they keep arriving in the middle of, the strange locations they find themselves, avoiding paradoxes, and most importantly trying not to kill each other.