Skeletor is the evil dark lord of the evil Human Liberation Front. Skeletor fights for humanity's very survival against the good and friendly alien ponies that plan to invade Earth to turn all humans into ponies against their will.
Princess Twilight Sparkle wakes up to find herself in an alternate Equestria, where everypony is nice, nothing ever bad happens and everything is just 'perfect'. Naturally the place bores her to death.
The Ponies had succeeded in converting every Human into Ponies. However, two strange unstoppable white walls of death are now expanding across Equus and Earth.
After being awoken by a loud and obnoxious alternate version of herself, Celestia visits the parallel universe her alternate self is from, to tell her egotistical copy of herself to shut up.
Fluttershy finds a cute, harmless, little animal in the Everfree Forest. Little did she know this creature is not as harmless as it looks. In fact, it's an extremely dangerous animal.
After a nasty encounter with Space Pirates, Fry, Leela and Bender ended up bumping into a certain Draconequus, whom sent them on a crash landing course to Equestria and to land them in the middle of the Everfree Forest.