This story is a sequel to Anon-A-Miss: Friendship is Home
Sunset Shimmer, Fiery Flames, and Discord are now a team. They will be handling bigger threats of Friendship with or without the Friendship Map. They will take on ponies or creatures that excluded Friendship in their lives and turned to Disharmony. Their adventures will begin and their team will build up.
This takes place right after Nero the Necromancer and Blaze made themselves known towards the final chapter of Anon-A-Miss Friendship is Home. The timeline continues on within this universe.
Another thing, some events as time moves forward will happen with Twilight and her Friendship Quests.